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. 2011 Nov 1;19(21):6254-60.
doi: 10.1016/j.bmc.2011.09.013. Epub 2011 Sep 10.

New Dammarane-Type Glucosides as Potential Activators of AMP-activated Protein Kinase (AMPK) From Gynostemma Pentaphyllum

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New Dammarane-Type Glucosides as Potential Activators of AMP-activated Protein Kinase (AMPK) From Gynostemma Pentaphyllum

Phi Hung Nguyen et al. Bioorg Med Chem. .

Abstract

AMP-activated protein kinase (AMPK) is a key sensor and regulator of glucose, lipid, and energy metabolism throughout the body. Activation of AMPK improves metabolic abnormalities associated with metabolic diseases including obesity and type-2 diabetes. The oriental traditional medicinal herbal plant, Gynostemma pentaphyllum, has shown a wide range of beneficial effects on glucose and lipid metabolism. In this study, we found that G. pentaphyllum contains two novel dammarane-type saponins designated as damulin A (1), 2α,3β,12β-trihydroxydammar-20(22)-E,24-diene-3-O-[β-D-glucopyranosyl-(1→2)-β-D-glucopyranoside], and damulin B (2), 2α,3β,12β-trihydroxydammar-20,24-diene-3-O-[β-D-glucopyranosyl-(1→2)-β-D-glucopyranoside], that strongly activate AMPK in cultured L6 myotube cells. Damulins A and B also increased β-oxidation and glucose uptake with increasing GluT4 translocation to the plasma membrane in L6 myotube cells. Taken together our results indicate that activation of AMPK by damulins A and B may contribute to beneficial effect of G. pentaphyllum on glucose and lipid metabolism.

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