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Review
, 58 (4), 339-44

A Kinase-Anchoring Proteins and Adenylyl Cyclase in Cardiovascular Physiology and Pathology

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Review

A Kinase-Anchoring Proteins and Adenylyl Cyclase in Cardiovascular Physiology and Pathology

Riad Efendiev et al. J Cardiovasc Pharmacol.

Abstract

3'-5'-Cyclic adenosine monophosphate (cAMP), generated by adenylyl cyclase (AC), serves as a second messenger in signaling pathways regulating many aspects of cardiac physiology, including contraction rate and action potential duration, and in the pathophysiology of hypertrophy and heart failure. A kinase-anchoring proteins localize the effect of cAMP in space and time by organizing receptors, AC, protein kinase A, and other components of the cAMP cascade into multiprotein complexes. In this review, we discuss how the interaction of A kinase-anchoring proteins with distinct AC isoforms affects cardiovascular physiology.

Figures

Figure 1
Figure 1
AC-AKAP complexes in cardiac myocytes. Abbreviations are: AC, adenylyl cyclase; AKAP, A kinase-anchoring protein; βAR, β-adrenergic receptor; EPAC, exchange protein directly activated by cAMP; Gs, stimulatory G protein; KCNQ1, α subunit of delayed rectifier K+ channel; LTCC, L-type calcium channel; PDE4D3, phosphodiesterase; PK, protein kinase; PLN, phospholamban; PP, protein phosphatase; RyR, ryanodine receptor; SERCA2, sarcoplasmic reticulum type 2 Ca2+-ATPase.

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