A kinase-anchoring proteins and adenylyl cyclase in cardiovascular physiology and pathology

J Cardiovasc Pharmacol. 2011 Oct;58(4):339-44. doi: 10.1097/FJC.0b013e31821bc3f0.


3'-5'-Cyclic adenosine monophosphate (cAMP), generated by adenylyl cyclase (AC), serves as a second messenger in signaling pathways regulating many aspects of cardiac physiology, including contraction rate and action potential duration, and in the pathophysiology of hypertrophy and heart failure. A kinase-anchoring proteins localize the effect of cAMP in space and time by organizing receptors, AC, protein kinase A, and other components of the cAMP cascade into multiprotein complexes. In this review, we discuss how the interaction of A kinase-anchoring proteins with distinct AC isoforms affects cardiovascular physiology.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • A Kinase Anchor Proteins / metabolism*
  • Action Potentials
  • Adenylyl Cyclases / chemistry
  • Adenylyl Cyclases / metabolism*
  • Animals
  • Cardiovascular Diseases / physiopathology
  • Cardiovascular System / metabolism
  • Cyclic AMP / metabolism*
  • Humans
  • Isoenzymes
  • Signal Transduction / physiology
  • Time Factors


  • A Kinase Anchor Proteins
  • Isoenzymes
  • Cyclic AMP
  • Adenylyl Cyclases