A method to adjust radiation dose-response relationships for clinical risk factors

Radiother Oncol. 2012 Mar;102(3):352-4. doi: 10.1016/j.radonc.2011.08.031. Epub 2011 Oct 6.

Abstract

Several clinical risk factors for radiation induced toxicity have been identified in the literature. Here, we present a method to quantify the effect of clinical risk factors on radiation dose-response curves and apply the method to adjust the dose-response for radiation pneumonitis for patients with/without pre-existing pulmonary co-morbidities.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Dose-Response Relationship, Radiation
  • Humans
  • Mathematics
  • Probability
  • Radiation Pneumonitis / etiology*
  • Risk Factors