PHGDH amplification and altered glucose metabolism in human melanoma

Pigment Cell Melanoma Res. 2011 Dec;24(6):1112-5. doi: 10.1111/j.1755-148X.2011.00919.x. Epub 2011 Oct 28.


The metabolic requirements of cancer cells differ from that of their normal counterparts. To support their proliferation, cancer cells switch to a fermentative metabolism that is thought to support biomass production. Instances where metabolic enzymes promote tumorigenesis remain rare. However, an enzyme involved in the de novo synthesis of serine, 3-phosphoglycerate dehydrogenase (PHGDH), was recently identified as a putative oncogene. The potential mechanisms by which PHGDH promotes cancer are discussed.

Publication types

  • Review

MeSH terms

  • Gene Amplification*
  • Glucose / metabolism*
  • Humans
  • Melanoma / enzymology*
  • Melanoma / genetics*
  • Metabolic Networks and Pathways
  • Phosphoglycerate Dehydrogenase / genetics*
  • Skin Neoplasms / enzymology*
  • Skin Neoplasms / genetics*


  • Phosphoglycerate Dehydrogenase
  • Glucose