Folic acid supplementation in early pregnancy and asthma in children aged 6 years

Am J Obstet Gynecol. 2012 Jan;206(1):72.e1-7. doi: 10.1016/j.ajog.2011.07.033. Epub 2011 Jul 29.


Objective: The objective of the study was to assess whether folic acid intake during the first trimester of pregnancy is related to asthma in the offspring by the age of 6 years.

Study design: This was a prospective cohort study of 1499 women who were followed up from the first trimester of pregnancy. Their children were followed up until they were 6 years old.

Results: Fifty-one percent of the women used folic acid in the month before conception and 88% in the third month of pregnancy. The adjusted odds ratio for asthma per 100 μm increase in the average daily intake of folic acid was 0.98 (95% confidence interval, 0.93-1.04). For categories of daily folate intake, there was no evidence of associations with childhood asthma or evidence of any dose response relation for any time period (all P(trend) > .05).

Conclusion: Our results do not support any association of folic acid supplementation in pregnancy and asthma risk in offspring by age 6 years.

Publication types

  • Research Support, N.I.H., Extramural

MeSH terms

  • Adult
  • Asthma / epidemiology*
  • Child
  • Cohort Studies
  • Dietary Supplements / adverse effects*
  • Female
  • Folic Acid / administration & dosage
  • Folic Acid / adverse effects*
  • Humans
  • Pregnancy
  • Prospective Studies
  • Risk
  • United States / epidemiology
  • Vitamin B Complex / administration & dosage
  • Vitamin B Complex / adverse effects*
  • Young Adult


  • Vitamin B Complex
  • Folic Acid