Skin moisturizing effects of panthenol-based formulations

J Cosmet Sci. 2011 Jul-Aug;62(4):361-70.


This study aims to evaluate the skin moisturizing efficacy of formulations containing different concentrations of panthenol. Formulations supplemented with or without 0.5%, 1.0%, or 5.0% panthenol were applied daily to the forearms of healthy subjects. Skin conditions in terms of moisture and transepidermal water loss (TEWL) were analyzed before and after 15- and 30-day periods of application. The formulations were also applied after skin washing with sodium laureth sulphate (SLES) to evaluate the immediate effects on TEWL and skin moisture. Panthenol-containing formulations (1.0% and 5.0%) produced significant decreases in TEWL after 30-day applications. In skin washed with SLES, significant reduction of TEWL was evident two hours after application of formulations loaded with panthenol when compared with control and vehicle. It is concluded that skin integrity is maintained by the improved protective effect of 1.0% panthenol added to the formulation.

Publication types

  • Controlled Clinical Trial
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Chemistry, Pharmaceutical*
  • Female
  • Homeostasis
  • Humans
  • Pantothenic Acid / administration & dosage
  • Pantothenic Acid / analogs & derivatives*
  • Pantothenic Acid / pharmacology
  • Placebos
  • Single-Blind Method
  • Skin / drug effects*
  • Water / chemistry


  • Placebos
  • Water
  • Pantothenic Acid
  • dexpanthenol