Homeostatic synaptic plasticity: from single synapses to neural circuits

Curr Opin Neurobiol. 2012 Jun;22(3):516-21. doi: 10.1016/j.conb.2011.09.006. Epub 2011 Oct 7.


Homeostatic synaptic plasticity remains an enigmatic form of synaptic plasticity. Increasing interest on the topic has fuelled a surge of recent studies that have identified key molecular players and the signaling pathways involved. However, the new findings also highlight our lack of knowledge concerning some of the basic properties of homeostatic synaptic plasticity. In this review we address how homeostatic mechanisms balance synaptic strengths between the presynaptic and the postsynaptic terminals and across synapses that share the same postsynaptic neuron.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Homeostasis*
  • Nerve Net / physiology*
  • Neuronal Plasticity / physiology*
  • Neurons / physiology*
  • Synapses / physiology*