[Anti-proliferation and chemo-sensitization effects of apigenin on human lung cancer cells]

Zhejiang Da Xue Xue Bao Yi Xue Ban. 2011 Sep;40(5):508-14.
[Article in Chinese]

Abstract

Objective: To investigate the antitumor effect of apigenin on human lung cancer cells.

Methods: The anti-proliferation and sensitization effects of apigenin on human lung cancer cells was accessed by counting cells after Trypan blue staining and MTS assay.

Results: (1) Apigenin significantly suppressed the proliferation of four types of human lung cancer cells (A549:P=0.041, H460:P=0.050, LTEP-a2:P=0.039, H292:P=0.016); (2) Apigenin significantly increased the susceptibility of human lung cancer cells to antitumor drugs (P<0.05 or P<0.01) in a synergistic way (almost all of the combination index values are less than 1).

Conclusion: Apigenin widely inhibits cell proliferation of various lung cancer cell lines in a dose-dependent manner and the combination treatment of apigenin and antitumor drugs is very effective in human lung cancer cells, and Nrf2-ARE pathway may contribute to the mechanism.

Publication types

  • English Abstract
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Antineoplastic Agents / pharmacology*
  • Apigenin / pharmacology*
  • Cell Line, Tumor / drug effects
  • Cell Proliferation / drug effects*
  • Drug Synergism
  • Humans
  • Lung Neoplasms / pathology

Substances

  • Antineoplastic Agents
  • Apigenin