Photodynamic therapy for best disease complicated by choroidal neovascularization in children

J Pediatr Ophthalmol Strabismus. 2012 Jul-Aug;49(4):216-21. doi: 10.3928/01913913-20111004-01. Epub 2011 Oct 11.

Abstract

Purpose: To describe the results of photodynamic therapy (PDT) with verteporfin for the treatment of choroidal neovascularization (CNV) associated with Best vitelliform macular dystrophy (BVMD) in children.

Methods: Five eyes of four children diagnosed as having BVMD complicated by CNV received a single session of PDT. Response to treatment was monitored with fluorescein angiography and optical coherence tomography.

Results: All eyes responded well to one session of PDT with significant increases in visual acuity in four of the five eyes. Increase or stabilization of visual acuity was preserved during a mean follow-up period of 25 months.

Conclusion: PDT may be an effective treatment for CNV associated with BVMD in children.

Publication types

  • Case Reports

MeSH terms

  • Child
  • Choroidal Neovascularization / diagnosis
  • Choroidal Neovascularization / drug therapy*
  • Choroidal Neovascularization / etiology
  • Electrooculography
  • Female
  • Fluorescein Angiography
  • Humans
  • Male
  • Photochemotherapy*
  • Photosensitizing Agents / therapeutic use
  • Porphyrins / therapeutic use
  • Retrospective Studies
  • Tomography, Optical Coherence
  • Verteporfin
  • Visual Acuity / physiology
  • Vitelliform Macular Dystrophy / complications
  • Vitelliform Macular Dystrophy / diagnosis
  • Vitelliform Macular Dystrophy / drug therapy*

Substances

  • Photosensitizing Agents
  • Porphyrins
  • Verteporfin