Filovirus hemorrhagic fever outbreak case management: a review of current and future treatment options

J Infect Dis. 2011 Nov;204 Suppl 3:S791-5. doi: 10.1093/infdis/jir297.

Abstract

Testing an innovative therapy for filovirus hemorrhagic fever (FHF) in an outbreak setting may be years away. Moreover, beyond anecdotal evidence, little is known about best practice for outbreak case management. Currently, Médecins Sans Frontières and others provide FHF patients with basic supportive treatment. We describe and discuss treatment possibilities, challenges, and potential next steps for FHF outbreak case management. More comprehensive supportive treatment, including vital sign monitoring, intensive care components, and goal-directed interventions may contribute to improved clinical outcome; the feasibility and effectiveness of this more comprehensive supportive treatment should be assessed. Our outlined summary may assist future FHF outbreak case management teams to create collaborative platforms and develop relevant treatment protocols aimed at improving clinical outcome.

Publication types

  • Review

MeSH terms

  • Antiviral Agents / pharmacology
  • Antiviral Agents / therapeutic use
  • Disease Outbreaks / prevention & control*
  • Filoviridae / drug effects
  • Filoviridae Infections / epidemiology*
  • Filoviridae Infections / prevention & control
  • Humans
  • Virus Replication / drug effects

Substances

  • Antiviral Agents