Hypoglycemia does not change the threshold for arousal from sleep in adolescents with type 1 diabetes

Diabetes Technol Ther. 2012 Feb;14(2):101-4. doi: 10.1089/dia.2011.0144. Epub 2011 Oct 11.


Background: Nocturnal hypoglycemia is a significant problem for children and adolescents with type 1 diabetes. The counterregulatory hormone response to hypoglycemia is blunted in both patients with type 1 diabetes and healthy subjects during sleep. It is not known whether the threshold for arousal from sleep is also modified by hypoglycemia. To address this question we compared the acoustic arousal threshold from sleep during hypoglycemia and euglycemia in adolescents with type 1 diabetes.

Methods: Adolescents with type 1 diabetes were studied on two occasions: under hypoglycemic and euglycemic conditions. During the hypoglycemia night, subjects underwent a hyperinsulinemic hypoglycemic clamp with nadir glucose level of 2.8 mmol/L. Hypoglycemia was initiated during stage 2 sleep and maintained during slow-wave sleep. During the euglycemia night, blood glucose was maintained at 5.5 mmol/L using the same clamp technique. The acoustic arousal threshold was determined during the first cycle of slow-wave sleep.

Results: Seven subjects (mean±SE, 14.2±0.8 years old, mean glycosylated hemoglobin 8.1±0.3%, duration of diagnosis 2.5±0.5 years) completed both study nights. Arousal was only noted during acoustic testing and did not occur during hypoglycemia alone. The acoustic arousal threshold during slow-wave sleep was similar under both conditions: 79±8 dB during euglycemia and 71±6 dB (P=0.353) during hypoglycemia.

Conclusion: In adolescents with type 1 diabetes, hypoglycemia does not impair arousal from slow-wave sleep induced by an external auditory stimulus.

Publication types

  • Comparative Study

MeSH terms

  • Acoustic Stimulation*
  • Adolescent
  • Arousal*
  • Blood Glucose / metabolism*
  • Circadian Rhythm
  • Diabetes Mellitus, Type 1 / blood
  • Diabetes Mellitus, Type 1 / drug therapy
  • Diabetes Mellitus, Type 1 / physiopathology*
  • Epinephrine / blood
  • Female
  • Glucose Clamp Technique
  • Humans
  • Hydrocortisone / blood
  • Hypoglycemia / drug therapy
  • Hypoglycemia / metabolism*
  • Hypoglycemic Agents / therapeutic use*
  • Insulin / therapeutic use
  • Male
  • Norepinephrine / blood
  • Polysomnography / methods
  • Reproducibility of Results
  • Sleep*


  • Blood Glucose
  • Hypoglycemic Agents
  • Insulin
  • Hydrocortisone
  • Norepinephrine
  • Epinephrine