Bilateral inferior petrosal sinus sampling

J Neurointerv Surg. 2012 May;4(3):215-8. doi: 10.1136/neurintsurg-2011-010033. Epub 2011 Apr 27.


Bilateral inferior petrosal sinus sampling, the gold standard assay in diagnosing pituitary secretion of adrenocorticotropic hormone in Cushing disease, is highly accurate and safe when performed by experienced interventionalists. We review the anatomic and technical considerations essential for safe and reliable practice.

Publication types

  • Review

MeSH terms

  • ACTH-Secreting Pituitary Adenoma / pathology
  • Adrenocorticotropic Hormone / physiology
  • Cavernous Sinus / pathology
  • Conscious Sedation
  • Corticotropin-Releasing Hormone
  • Cushing Syndrome / diagnosis
  • Humans
  • Petrosal Sinus Sampling / adverse effects
  • Petrosal Sinus Sampling / methods*
  • Pituitary Gland / physiopathology


  • Adrenocorticotropic Hormone
  • Corticotropin-Releasing Hormone