Clinical pharmacokinetics of drugs used in the treatment of gastrointestinal diseases (Part II)

Clin Pharmacokinet. 1990 Aug;19(2):94-125. doi: 10.2165/00003088-199019020-00002.


Part I of this article, which appeared in the previous issue of the Journal, covered the following agents: histamine H2-receptor antagonists (cimetidine, ranitidine, famotidine, nizatidine); muscarinic-M1-receptor antagonists (pirenzepine); proton pump inhibitors (omeprazole); site-protective agents (colloidal bismuth subcitrate, sucralfate); antacids and prostaglandin analogues; antiemetics and prokinetics (metoclopramide, domperidone, cisapride); and antispasmodics. In Part II, we consider the anti-inflammatory salicylates, nonspecific antidiarrhoeal agents, laxatives and cathartics.

Publication types

  • Review

MeSH terms

  • Anti-Inflammatory Agents, Non-Steroidal / pharmacokinetics
  • Anti-Inflammatory Agents, Non-Steroidal / therapeutic use
  • Antidiarrheals / therapeutic use
  • Cathartics / therapeutic use
  • Gastrointestinal Agents / pharmacokinetics*
  • Gastrointestinal Agents / therapeutic use
  • Gastrointestinal Diseases / drug therapy*
  • Gastrointestinal Diseases / metabolism
  • Humans
  • Salicylates / pharmacokinetics
  • Salicylates / therapeutic use


  • Anti-Inflammatory Agents, Non-Steroidal
  • Antidiarrheals
  • Cathartics
  • Gastrointestinal Agents
  • Salicylates