Long term effect of monosodium glutamate in liver of albino mice after neo-natal exposure

Nepal Med Coll J. 2011 Mar;13(1):11-6.


Mono Sodium Glutamate (MSG) is a naturally occurring excitatory neurotransmitter. It is extensively used as a food additive and flavoring agent for its UMAMI taste. Simultaneously it is being implicated for varied pathological condition like obesity, gonadal dysfunction, learning difficulty etc. It produces oxygen derived free radicals and metabolized in liver. Neonate mice are sensitive and suffer from adverse effects. Present work was undertaken to study the long term effects on histology of liver following MSG injection in neonates. The changes in the liver parenchyma of 75 days old mice showed variable changes. Areas around central vein were most affected. The liver cords were disrupted, dilated sinusoids, prominent Kupffer cells with accumulation of particulate matter.There were inflammatory cells around central vein. The hepatocyte cell membrane were disrupted, cytoplasm vacuolated, nucleus were pyknotic. Even the normal looking cells showed depletion of PAS +ve material in the cytoplasm.The long term effect on histology showed moderate and patchy hepatocellular damage.

MeSH terms

  • Animals
  • Female
  • Hepatocytes / pathology
  • Liver / drug effects*
  • Liver / pathology*
  • Male
  • Mice
  • Sodium Glutamate / pharmacology*
  • Time Factors


  • Sodium Glutamate