Aggressive peripheral CD70-positive T-cell lymphoma associated with severe chronic active EBV infection

Pediatr Blood Cancer. 2012 Oct;59(4):758-61. doi: 10.1002/pbc.23352. Epub 2011 Oct 12.


Severe chronic active Epstein-Barr virus infection (CAEBV) in T or NK cells is a rare complication of latent EBV infection. CAEBV associated T-cell lymphoproliferative disease (LPD) consists of polyclonal lesions as well as aggressive lymphomas. Here, we report such a patient. In addition, we show that this primary CAEBV associated T-cell lymphoma expresses CD70 and is sensitive to killing by CD70-specific T cells, identifying CD70 as a potential immunotherapeutic target for CAEBV-associated T-cell lymphoma.

Publication types

  • Case Reports
  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't

MeSH terms

  • CD27 Ligand / metabolism*
  • Child, Preschool
  • Chronic Disease
  • Epstein-Barr Virus Infections / complications*
  • Epstein-Barr Virus Infections / immunology
  • Epstein-Barr Virus Infections / therapy
  • Hematopoietic Stem Cell Transplantation
  • Humans
  • Lymphoma, T-Cell / etiology
  • Lymphoma, T-Cell / immunology
  • Lymphoma, T-Cell / virology*
  • Male
  • T-Lymphocytes / immunology*


  • CD27 Ligand