Skip to main page content
Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2011 Dec;34(12):2551-4.
doi: 10.2337/dc11-0652. Epub 2011 Oct 12.

Low Water Intake and Risk for New-Onset Hyperglycemia

Collaborators, Affiliations
Free PMC article

Low Water Intake and Risk for New-Onset Hyperglycemia

Ronan Roussel et al. Diabetes Care. .
Free PMC article

Abstract

Objective: Water intake alters vasopressin secretion. Recent findings reveal an independent association between plasma copeptin, a surrogate for vasopressin, and risk of diabetes.

Research design and methods: Participants were 3,615 middle-aged men and women, with normal baseline fasting glycemia (FG), who were recruited in a 9-year follow-up study. Odds ratios (ORs) and 95% CIs for the incidence of hyperglycemia (FG ≥6.1 mmol/L or treatment for diabetes) were calculated according to daily water intake classes based on a self-administered questionnaire.

Results: During follow-up, there were 565 incident cases of hyperglycemia. After adjustment for confounding factors, ORs (95% CIs) for hyperglycemia associated with classes of water intake (<0.5 L, n = 677; 0.5 to <1.0 L, n = 1,754; and >1.0 L, n = 1,184) were 1.00, 0.68 (0.52-0.89), and 0.79 (0.59-1.05), respectively (P = 0.016).

Conclusions: Self-reported water intake was inversely and independently associated with the risk of developing hyperglycemia.

Similar articles

See all similar articles

Cited by 54 articles

See all "Cited by" articles

References

    1. Enhörning S, Wang TJ, Nilsson PM, et al. Plasma copeptin and the risk of diabetes mellitus. Circulation 2010;121:2102–2108 - PMC - PubMed
    1. Zerbe RL, Vinicor F, Robertson GL. Plasma vasopressin in uncontrolled diabetes mellitus. Diabetes 1979;28:503–508 - PubMed
    1. Bankir L, Bardoux P, Ahloulay M. Vasopressin and diabetes mellitus. Nephron 2001;87:8–18 - PubMed
    1. Whitton PD, Rodrigues LM, Hems DA. Stimulation by vasopressin, angiotensin and oxytocin of gluconeogenesis in hepatocyte suspensions. Biochem J 1978;176:893–898 - PMC - PubMed
    1. Spruce BA, McCulloch AJ, Burd J, et al. The effect of vasopressin infusion on glucose metabolism in man. Clin Endocrinol (Oxf) 1985;22:463–468 - PubMed

Publication types

Feedback