Seroconversion to HCoV-NL63 in Rhesus Macaques

Viruses. 2009 Dec;1(3):647-56. doi: 10.3390/v1030647. Epub 2009 Oct 30.


HCoV-NL63 is a recently identified respiratory virus. Its pathogenesis has not been fully unraveled because an animal model is currently lacking. Here we examined whether rhesus macaques encounter HCoV-NL63 infections during life, by examining the levels of antibodies to HCoV-NL63 in time. The animals were followed for 7 up till 19 years, and in three animals we observed a steep rise in antibodies during follow up, indicative of a natural infection with HCoV-NL63.

Keywords: HCoV-NL63; rhesus macaques.