The association between stage 3 or higher retinopathy of prematurity and other disorders of prematurity

Can J Ophthalmol. 2011 Oct;46(5):419-24. doi: 10.1016/j.jcjo.2011.07.014. Epub 2011 Aug 4.


Objective: To evaluate the association between stage III or higher retinopathy of prematurity (ROP) and other prematurity disorders and parameters.

Design: Retrospective, case-control study.

Participants: The subjects of the study were 55 consecutive premature neonates with stage III or higher ROP and 110 consecutive premature neonates without ROP.

Methods: We compared consecutive premature neonates regarding the presence of ROP and other disorders as well as demographic and laboratory parameters.

Results: Gestational age (p < 0.001); birth weight (p < 0.001); male sex (p = 0.031); bilirubin levels (p < 0.001); breast feeding (p < 0.001); clinical and laboratory sepsis (p < 0.001); number of sepsis events (p < 0.001); ventilation need (p < 0.001); number of ventilation days (p < 0.001); theophylline and surfactant use (p < 0.001); blood transfusions (p < 0.001); number of blood transfusions (p < 0.001); intraventricular hemorrhage and bronchopulmonary dysplasia (p = 0.001); and other factors differed in the two groups. The logistic regression model showed a correlation between low gestational age (OD 0.474, CI 0.359-0.626); male sex (OD 2.991, CI 1.077-8.305); blood transfusion (OD 14.159, CI 1.570-127.7); and sepsis (OD 12.376, CI 2.532-60.503).

Conclusions: Certain disorders and parameters, such as sepsis and blood transfusions, may be predict the appearance of stage III or higher ROP. Close monitoring of neonates with these findings is imperative. Early detection and treatment of sepsis and reduction of blood transfusions may decrease the incidence of ROP that requires treatment.

Publication types

  • Comparative Study

MeSH terms

  • Birth Weight
  • Blood Transfusion*
  • Case-Control Studies
  • Female
  • Gestational Age
  • Humans
  • Incidence
  • Infant, Extremely Low Birth Weight
  • Infant, Newborn
  • Infant, Premature
  • Male
  • Retinopathy of Prematurity / classification
  • Retinopathy of Prematurity / diagnosis*
  • Retrospective Studies
  • Sepsis / diagnosis*
  • Sex Factors