Structural insights into regulation and action of SWI2/SNF2 ATPases

Curr Opin Struct Biol. 2011 Dec;21(6):719-27. doi: 10.1016/ Epub 2011 Oct 11.


This review focuses on recent structural insights into regulation and nucleic acid binding of Superfamily 2 (SF2)-type helicases as they relate to chromatin remodelers. We review structural features of the Chd1 chromatin remodeler regarding regulation of the ATPase motor, and discuss related strategies observed for other SF2 ATPases. Since no SWI2/SNF2 ATPases have yet been captured bound to DNA in a state competent for ATP hydrolysis, we turn to structural examples from the DEAD-box RNA helicase family, and suggest that SWI2/SNF2-specific inserts may be poised to alter canonical duplex DNA structure.

Publication types

  • Research Support, N.I.H., Extramural
  • Review

MeSH terms

  • Adenosine Triphosphatases / chemistry*
  • Adenosine Triphosphatases / metabolism
  • Animals
  • Binding Sites
  • Chromatin Assembly and Disassembly
  • DEAD-box RNA Helicases / chemistry
  • DEAD-box RNA Helicases / metabolism
  • DNA Helicases / chemistry
  • DNA Helicases / metabolism
  • DNA-Binding Proteins / chemistry*
  • DNA-Binding Proteins / metabolism
  • Humans
  • Models, Molecular
  • Protein Conformation


  • DNA-Binding Proteins
  • Adenosine Triphosphatases
  • DNA Helicases
  • DEAD-box RNA Helicases