Membrane trafficking: decoding vesicle identity with contrasting chemistries

Curr Biol. 2011 Oct 11;21(19):R811-3. doi: 10.1016/j.cub.2011.08.045.


Proteins involved in membrane traffic must distinguish between different classes of vesicles. New work now shows that α-synuclein and ALPS motifs represent two extreme types of amphipathic helix that are tuned to detect both the curvature of transport vesicles as well as their bulk lipid content.

MeSH terms

  • Amino Acid Motifs
  • Binding Sites
  • Cytoplasmic Vesicles / chemistry
  • Cytoplasmic Vesicles / metabolism*
  • Golgi Apparatus / metabolism
  • Hydrophobic and Hydrophilic Interactions
  • Membrane Lipids / metabolism*
  • Saccharomyces cerevisiae / cytology*
  • Saccharomyces cerevisiae / metabolism*
  • Secretory Vesicles / metabolism
  • alpha-Synuclein / metabolism*


  • Membrane Lipids
  • alpha-Synuclein