Glomerular lesions in nonobese diabetic mouse: before and after the onset of hyperglycemia

Lab Invest. 1990 Aug;63(2):204-12.


The natural history of renal lesions in nonobese diabetic mice was assessed. This strain develops a spontaneous overt insulin-dependent diabetes that has a female predominance and an autoimmune pathogenesis. We compared mice that had a normal glucose tolerance test with mice that had a diabetes of 2 to 15 weeks' duration. The glomerular surface area was increased in all diabetic mice regardless of the duration of hyperglycemia. There was an increase in the albumin/creatinine ratio in the urine of diabetic mice. Finally, nonobese diabetic mice all showed mesangial sclerosis that was more pronounced in the diabetic mice. This suggests that this strain is susceptible to glomerulosclerosis and that the occurrence of hyperglycemia results in an increase of glomerular size, mesangial sclerosis, and proteinuria, soon after glycosuria is first demonstrated.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Animals
  • Basement Membrane / metabolism
  • Collagen / metabolism
  • Creatinine / blood
  • Diabetes Mellitus, Experimental / metabolism
  • Diabetes Mellitus, Experimental / pathology*
  • Female
  • Fluorescent Antibody Technique
  • Hyperglycemia / pathology*
  • Immunoglobulins / metabolism
  • Kidney Glomerulus / pathology*
  • Male
  • Mice
  • Mice, Mutant Strains
  • Microscopy, Electron
  • Organ Size
  • Proteinuria / pathology
  • Sclerosis
  • Time Factors


  • Immunoglobulins
  • Collagen
  • Creatinine