Acromegaly due to production of a growth hormone releasing factor by a bronchial carcinoid tumor

Clin Endocrinol (Oxf). 1979 Jan;10(1):61-7. doi: 10.1111/j.1365-2265.1979.tb03034.x.


We have studied growth hormone production in a patient with a bronchial carcinoid and acromegaly. The absence of growth hormone from the carcinoid tumour was demonstrated by extraction, cell culture and immunoperosidase techniques. Using a linked perfusion culture system, effluent from the bronchial carcinoid tumour culture stimulated a rapid release of growth hormone from a rat pituitary monolayer. This is the first time evidence of growth hormone releasing activity by a bronchial carcinoid has been demonstrated in a production.

Publication types

  • Case Reports

MeSH terms

  • Acromegaly / etiology*
  • Adrenocorticotropic Hormone / metabolism
  • Animals
  • Bronchial Neoplasms / complications
  • Bronchial Neoplasms / metabolism*
  • Carcinoid Tumor / complications
  • Carcinoid Tumor / metabolism*
  • Cells, Cultured
  • Dopamine / pharmacology
  • Growth Hormone / biosynthesis
  • Growth Hormone / metabolism
  • Growth Hormone-Releasing Hormone / metabolism*
  • Humans
  • Male
  • Neoplasm Metastasis
  • Pituitary Gland, Anterior / drug effects
  • Pituitary Gland, Anterior / metabolism
  • Rats
  • Secretory Rate / drug effects


  • Adrenocorticotropic Hormone
  • Growth Hormone
  • Growth Hormone-Releasing Hormone
  • Dopamine