An old NSAID revisited: crystal structure of aldose reductase in complex with sulindac at 1.0 Å supports a novel mechanism for its anticancer and antiproliferative effects

ChemMedChem. 2011 Dec 9;6(12):2155-7. doi: 10.1002/cmdc.201100374. Epub 2011 Oct 13.
No abstract available

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Aldehyde Reductase / antagonists & inhibitors*
  • Aldehyde Reductase / metabolism
  • Antineoplastic Agents / chemistry*
  • Antineoplastic Agents / pharmacology
  • Binding Sites
  • Cell Proliferation / drug effects
  • Computer Simulation
  • Crystallography, X-Ray
  • Databases, Protein
  • Enzyme Inhibitors / chemistry*
  • Enzyme Inhibitors / pharmacology
  • Humans
  • Protein Structure, Tertiary
  • Sulindac / chemistry*
  • Sulindac / pharmacology

Substances

  • Antineoplastic Agents
  • Enzyme Inhibitors
  • Sulindac
  • Aldehyde Reductase