Evaluation of deleted in malignant brain tumors 1 (DMBT1) gene expression in bladder carcinoma cases: preliminary study

Biomarkers. 2011 Nov;16(7):610-5. doi: 10.3109/1354750X.2011.620627. Epub 2011 Oct 15.


This study was undertaken to evaluate the expression of DMBT1 in bladder cancer and its correlation with clinico-pathological parameters analyzed in bladder carcinoma patients. We investigated DMBT1 in 56 paraffin embedded specimens of transitional cell carcinoma of the urinary bladder. We assessed DMBT1 gene expression at mRNA level by RT-PCR. Our results show 100% expression of DMBT1 in bladder carcinoma samples. Due to this preliminary results; gene expression was compared to tumor grade, and a significant difference was detected between grade 1 and 3 (p = 0.028). The down-regulation of DMBT1 gene expression in carcinomas suggests the possible role in bladder cancer.

MeSH terms

  • Adult
  • Aged
  • Aged, 80 and over
  • Calcium-Binding Proteins
  • Carcinoma, Transitional Cell / genetics*
  • Carcinoma, Transitional Cell / pathology
  • DNA-Binding Proteins
  • Down-Regulation
  • Female
  • Gene Expression Regulation, Neoplastic*
  • Humans
  • Male
  • Middle Aged
  • Neoplasm Grading
  • RNA, Messenger / genetics
  • RNA, Messenger / metabolism
  • Receptors, Cell Surface / genetics*
  • Reverse Transcriptase Polymerase Chain Reaction
  • Tumor Suppressor Proteins
  • Urinary Bladder Neoplasms / genetics*
  • Urinary Bladder Neoplasms / pathology


  • Calcium-Binding Proteins
  • DMBT1 protein, human
  • DNA-Binding Proteins
  • RNA, Messenger
  • Receptors, Cell Surface
  • Tumor Suppressor Proteins