Glucagon and the glucagon-like peptides

Pancreas. 1990 Jul;5(4):484-8. doi: 10.1097/00006676-199007000-00018.


Glucagon and the glucagon-like peptides are encoded within a larger precursor, proglucagon. The proglucagon gene is expressed in the pancreas, intestine, and brain, giving rise to a single proglucagon mRNA transcript that is identical in all tissues. Tissue-specific posttranslational processing of proglucagon accounts for the different molecular forms of the glucagon-related peptides present in each tissue. Glucagon-like peptide I has been demonstrated to have potent insulinotropic properties, but the biological importance of other glucagon-related peptides remains unclear. The recent advances that have increased our understanding of the biology of glucagon and the glucagon-like peptides are reviewed.

Publication types

  • Review

MeSH terms

  • Animals
  • Brain / metabolism
  • Gene Expression
  • Glucagon* / genetics
  • Glucagon* / physiology
  • Glucagon-Like Peptides
  • Humans
  • Intestinal Mucosa / metabolism
  • Pancreas / metabolism
  • Peptides* / genetics
  • Peptides* / physiology
  • Proglucagon
  • Protein Precursors / genetics
  • Protein Processing, Post-Translational


  • Peptides
  • Protein Precursors
  • Proglucagon
  • Glucagon-Like Peptides
  • glucagon-like-immunoreactivity
  • Glucagon