Hiding in plain sight: how HIV evades innate immune responses

Cell. 2011 Oct 14;147(2):271-4. doi: 10.1016/j.cell.2011.09.010.


Two groups have identified SAMHD1, a protein encoded by an Aicardi-Goutières Syndrome susceptibility gene, as the factor that restricts infection of macrophages and dendritic cells with HIV-1. Here we discuss implications of this discovery for induction of antiviral protective immunity.

Publication types

  • Review

MeSH terms

  • AIDS Vaccines / immunology
  • Adaptive Immunity
  • Autoimmune Diseases of the Nervous System / genetics
  • Dendritic Cells / immunology
  • HIV Infections / immunology*
  • HIV-1*
  • Humans
  • Immune Evasion*
  • Immunity, Innate*
  • Macrophages / immunology
  • Macrophages / virology
  • Nervous System Malformations / genetics


  • AIDS Vaccines

Supplementary concepts

  • Aicardi-Goutieres syndrome