Vitamin D-gene interactions in multiple sclerosis

J Neurol Sci. 2011 Dec 15;311(1-2):32-6. doi: 10.1016/j.jns.2011.08.041. Epub 2011 Oct 13.


Vitamin D has been studied for over a century and its functions related to calcium homeostasis are well established. Over the last 30 years or so it has become increasingly clear that it has a wider role in physiology and, importantly, also in disease. Vitamin D deficiency has been linked to multiple sclerosis (MS); however the molecular mechanisms of this association were poorly understood. Recent technological advances have provided major insights as to how vitamin D may exert its role, particularly through the actions of the vitamin D receptor (VDR). In this review we aim to highlight the importance of the interaction between vitamin D and MS associated genes which provide a biological basis for the association between vitamin D and MS risk.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Comorbidity / trends
  • Genetic Predisposition to Disease / genetics
  • Genome-Wide Association Study
  • Humans
  • Multiple Sclerosis / epidemiology*
  • Multiple Sclerosis / genetics*
  • Multiple Sclerosis / metabolism
  • Receptors, Calcitriol / genetics
  • Receptors, Calcitriol / metabolism*
  • Vitamin D / metabolism*
  • Vitamin D Deficiency / epidemiology*
  • Vitamin D Deficiency / genetics*
  • Vitamin D Deficiency / metabolism


  • Receptors, Calcitriol
  • Vitamin D