Posttranslational regulation of AMPA receptor trafficking and function

Curr Opin Neurobiol. 2012 Jun;22(3):470-9. doi: 10.1016/j.conb.2011.09.008. Epub 2011 Oct 14.


In the mammalian central nervous system, the majority of fast excitatory synaptic transmission is mediated by glutamate acting on AMPA-type ionotropic glutamate receptors. The abundance of AMPA receptors at the synapse can be modulated through receptor trafficking, which dynamically regulates many fundamental brain functions, including learning and memory. Reversible posttranslational modifications, including phosphorylation, palmitoylation and ubiquitination of AMPA receptor subunits are important regulatory mechanisms for controlling synaptic AMPA receptor expression and function. In this review, we highlight recent advances in the study of AMPA receptor posttranslational modifications and discuss how these modifications regulate AMPA receptor trafficking and function at synapses.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, N.I.H., Intramural
  • Review

MeSH terms

  • Animals
  • Models, Biological
  • Protein Biosynthesis / physiology*
  • Protein Transport / physiology
  • Receptors, AMPA / physiology*
  • Synapses / metabolism*


  • Receptors, AMPA