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. 2011;21(6):431-9.
doi: 10.2188/jea.je20110010. Epub 2011 Oct 15.

Weight Gain and Risk of Impaired Fasting Glucose After Smoking Cessation

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Free PMC article

Weight Gain and Risk of Impaired Fasting Glucose After Smoking Cessation

Mitsumasa Kamaura et al. J Epidemiol. .
Free PMC article

Abstract

Background: Observation of early changes in fasting plasma glucose level induced by post-smoking cessation weight gain is useful in predicting the risks of diabetes mellitus (DM) and impaired fasting glucose (IFG). We investigated the effect of post-smoking cessation weight gain on early changes in the risk of a high fasting plasma glucose (IFG) level (≥100 mg/dL).

Methods: In 946 subjects who underwent repeated health examinations after smoking cessation, changes in body mass index (BMI) and the odds ratio (OR) for IFG risk (adjusted for sex, age, BMI, fasting plasma glucose at year 1, and alcohol consumption) were calculated every year for 3 years after smoking cessation.

Results: After smoking cessation, the rate of BMI increase significantly increased in quitters: 2.36% at year 2 (never smokers: 0.22%, current smokers: 0.39%) and 0.46% at year 3 (never smokers: 0.14%, current smokers: 0.32%). However, it decreased by 0.15% at year 4 (never smokers: 0.12%, current smokers: 0.26%). The ORs for quitters did not significantly increase at any time during the follow-up period. However, among quitters who had smoked at least 20 cigarettes per day, it was significantly higher (OR 1.51, 95% confidence interval 1.1-2.01 at year 1 and 1.71, 1.23-2.38 at year 2).

Conclusions: The time course of the risk of IFG after smoking cessation was similar to that for the rate of BMI increase. In contrast to the findings of previous reports, the increase in IFG risk after smoking cessation was brief and disappeared in the absence of a significant increase in BMI.

Figures

Figure 1.
Figure 1.. The process of sample selection (The study flow diagram)
Figure 2.
Figure 2.. Time course of rate of BMI increase and odds ratio of IFG risk after smoking cessation. Significance was evaluated by logistic regression (vs. never smokers) *P < 0.05 **P < 0.01 ***P < 0.001 adjusted for sex, age, BMI, fasting glucose at first year, and alcohol consumption.

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References

    1. Reas DL , Nygård JF , Sørensen T. Do quitters have anything to lose? Changes in body mass index for daily, never, and former smokers over an 11-year period (1990–2001) . Scand J Public Health. 2009;37:774–7 10.1177/1403494809344654 - DOI - PubMed
    1. Kadowaki T , Watanabe M , Okayama A , Hishida K , Okamura T , Miyamatsu N , et al. Continuation of smoking cessation and following weight change after intervention in a healthy population with high smoking prevalence . J Occup Health. 2006;48(5):402–6 10.1539/joh.48.402 - DOI - PubMed
    1. Mizoue T , Tokui N , Hino Y , Ueda R , Yoshimui T. Body mass decrease after initial gain following smoking cessation . Int J Epidemiol. 1998;27(6):984–8 10.1093/ije/27.6.984 - DOI - PubMed
    1. Pereira MA , Ebbeling CB , Van Horn L , Slattery ML , Jacobs DR Jr , Kartashov AI , et al. Fast-food habits, weight gain, and insulin resistance (the CARDIA study): 15-year prospective analysis . Lancet. 2005. Jan 1–7;365(9453):36–42 10.1016/S0140-6736(04)17663-0 - DOI - PubMed
    1. Koh-Banerjee P , Wang Y , Hu FB , Spiegelman D , Willett WC , Rimm EB. Changes in body weight and body fat distribution as risk factors for clinical diabetes in US men . Am J Epidemiol. 2004. Jun 15;159:1150–9 10.1093/aje/kwh167 - DOI - PubMed
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