Y-chromosomal microsatellite diversity in three culturally defined regions of historical Tibet

Forensic Sci Int Genet. 2012 Jul;6(4):437-46. doi: 10.1016/j.fsigen.2011.09.002. Epub 2011 Oct 17.


In the present study, we analyzed 17 Y-STR loci in 350 Tibetan males from three culturally defined regions of historical Tibet: Amdo (88), Kham (109) and U-Tsang (153). A total of 299 haplotypes were observed, 272 (90.9%) of which were unique. Only one Y-STR profile is shared across the three Tibetan groups and, incidentally, is also the most frequent haplotype (4.0%), represented by two, five and seven individuals from U-Tsang, Kham and Amdo, respectively. The overall haplotype diversity for the three Tibetan populations at 17 Y-STR loci was 0.9978 and the corresponding values for the extended (11-loci) and minimal (9-loci) haplotypes were 0.9935 and 0.9909, respectively. Both neighbor-joining and Rst pairwise analyses suggest a close genetic relationship between the Amdo and Kham populations, while U-Tsang is genetically distinct from the aforementioned groups. The results demonstrate that the 17 Y-STR loci analyzed are highly polymorphic in all three Tibetan populations examined and hence useful for forensic cases, paternity testing and population genetic studies.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Chromosomes, Human, Y*
  • DNA Fingerprinting
  • Ethnicity / genetics*
  • Gene Frequency
  • Genetic Variation*
  • Genetics, Population*
  • Haplotypes
  • Humans
  • Male
  • Microsatellite Repeats*
  • Phylogeny
  • Tibet