Novel terpenoids from Calocedrus macrolepis var. formosana

Chem Biodivers. 2011 Oct;8(10):1901-7. doi: 10.1002/cbdv.201000237.

Abstract

Calocetriol (1), diacetylcalocediol (2), and ferrugimenthenol (3) were isolated from the bark of Calocedrus macrolepis var. formosana. Among them, 1 and 2 are secoabietane-type diterpenoids, and 3, with a novel C(20)-C(10) skeleton, is classified as a meroterpenoid. The structures of 1-3 were elucidated by spectroscopic analyses, and their biological activities were also evaluated. Compound 3 exhibited significant cytotoxic activity against human oral epidermoid carcinoma KB cells with an IC(50) value of 9.0±0.1 μM.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Antineoplastic Agents, Phytogenic / chemistry
  • Antineoplastic Agents, Phytogenic / pharmacology
  • Carcinoma, Squamous Cell / drug therapy
  • Carcinoma, Squamous Cell / pathology
  • Cell Line, Tumor
  • Cupressaceae / chemistry*
  • Drug Screening Assays, Antitumor
  • Humans
  • Inhibitory Concentration 50
  • Molecular Structure
  • Mouth Neoplasms / drug therapy
  • Mouth Neoplasms / pathology
  • Nuclear Magnetic Resonance, Biomolecular
  • Plant Bark / chemistry
  • Terpenes / chemistry*
  • Terpenes / pharmacology*

Substances

  • Antineoplastic Agents, Phytogenic
  • Terpenes