Abstract
Tricladins A and B (1 and 2, resp.), new imidazolone-containing alkaloids, together with five known metabolites, bacillamides A, B (3 and 4, resp.), 20-hydroxyaflavinine (5), N-(2-phenylethyl)acetamide (6), and N(b)-acetyltryptamine (7), have been isolated from the crude extract of the ascomycete fungus Tricladium sp. The structures of 1 and 2 were elucidated primarily by NMR and MS methods. Compound 2 showed marginal cytotoxicity against MDA-MB-231 human breast cancer cells, whereas the known metabolite 4 displayed an inhibitory effect on HIV-1 replication in C8166 cells.
Copyright © 2011 Verlag Helvetica Chimica Acta AG, Zürich.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Alkaloids / chemistry*
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Alkaloids / isolation & purification
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Alkaloids / pharmacology*
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Anti-HIV Agents / chemistry
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Anti-HIV Agents / pharmacology
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Antineoplastic Agents, Phytogenic / chemistry
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Antineoplastic Agents, Phytogenic / pharmacology
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Ascomycota / chemistry*
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Breast Neoplasms / drug therapy
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Breast Neoplasms / pathology
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Cell Line, Tumor
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Drug Evaluation, Preclinical
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Female
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HIV-1 / drug effects
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Humans
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Imidazoles / chemistry*
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Imidazoles / pharmacology
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Magnetic Resonance Spectroscopy
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Mass Spectrometry
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Molecular Structure
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Thiazoles / chemistry
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Thiazoles / pharmacology
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Tryptamines / chemistry
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Tryptamines / pharmacology
Substances
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Alkaloids
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Anti-HIV Agents
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Antineoplastic Agents, Phytogenic
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Imidazoles
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Thiazoles
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Tryptamines
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bacillamide B
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imidazolone
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tricladin A
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tricladin B
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N-acetyltryptamine