QUADAS-2: a revised tool for the quality assessment of diagnostic accuracy studies

Ann Intern Med. 2011 Oct 18;155(8):529-36. doi: 10.7326/0003-4819-155-8-201110180-00009.

Abstract

In 2003, the QUADAS tool for systematic reviews of diagnostic accuracy studies was developed. Experience, anecdotal reports, and feedback suggested areas for improvement; therefore, QUADAS-2 was developed. This tool comprises 4 domains: patient selection, index test, reference standard, and flow and timing. Each domain is assessed in terms of risk of bias, and the first 3 domains are also assessed in terms of concerns regarding applicability. Signalling questions are included to help judge risk of bias. The QUADAS-2 tool is applied in 4 phases: summarize the review question, tailor the tool and produce review-specific guidance, construct a flow diagram for the primary study, and judge bias and applicability. This tool will allow for more transparent rating of bias and applicability of primary diagnostic accuracy studies.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Bias
  • Diagnosis*
  • Evidence-Based Medicine
  • Humans
  • Patient Selection
  • Quality Control
  • Reference Standards
  • Review Literature as Topic*
  • Surveys and Questionnaires*
  • Time Factors