Exercise training increases glucose transporter protein GLUT-4 in skeletal muscle of obese Zucker (fa/fa) rats

FEBS Lett. 1990 Jul 30;268(1):13-6. doi: 10.1016/0014-5793(90)80960-q.


The present study examined the level of GLUT-4 glucose transporter protein in gastrocnemius muscles of 36 week old genetically obese Zucker (fa/fa) rats and their lean (Fa/-) littermates, and in obese Zucker rats following 18 or 30 weeks of treadmill exercise training. Despite skeletal muscle insulin resistance, the level of GLUT-4 glucose transporter protein was similar in lean and obese Zucker rats. In contrast, exercise training increased GLUT-4 protein levels by 1.7 and 2.3 fold above sedentary obese rats. These findings suggest endurance training stimulates expression of skeletal muscle GLUT-4 protein which may be responsible for the previously observed increase in insulin sensitivity with training.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Animals
  • Blood Glucose / metabolism
  • Blotting, Western
  • Body Weight
  • Insulin / blood
  • Monosaccharide Transport Proteins / metabolism*
  • Muscles / metabolism*
  • Obesity / metabolism
  • Physical Conditioning, Animal*
  • Rats
  • Rats, Mutant Strains


  • Blood Glucose
  • Insulin
  • Monosaccharide Transport Proteins