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, 2011, 567305

E-cadherin/β-catenin Complex and the Epithelial Barrier


E-cadherin/β-catenin Complex and the Epithelial Barrier

Xinrui Tian et al. J Biomed Biotechnol.


E-Cadherin/β-catenin complex plays an important role in maintaining epithelial integrity and disrupting this complex affect not only the adhesive repertoire of a cell, but also the Wnt-signaling pathway. Aberrant expression of the complex is associated with a wide variety of human malignancies and disorders of fibrosis resulting from epithelial-mesenchymal transition. These associations provide insights into the complexity that is likely responsible for the fibrosis/tumor suppressive action of E-cadherin/β-catenin.


Figure 1
Figure 1
E-cadherin/β-catenin complex in epithelial cell-cell adhesion and Wnt signalling.

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