E-cadherin/β-catenin complex and the epithelial barrier

J Biomed Biotechnol. 2011;2011:567305. doi: 10.1155/2011/567305. Epub 2011 Oct 11.

Abstract

E-Cadherin/β-catenin complex plays an important role in maintaining epithelial integrity and disrupting this complex affect not only the adhesive repertoire of a cell, but also the Wnt-signaling pathway. Aberrant expression of the complex is associated with a wide variety of human malignancies and disorders of fibrosis resulting from epithelial-mesenchymal transition. These associations provide insights into the complexity that is likely responsible for the fibrosis/tumor suppressive action of E-cadherin/β-catenin.

Publication types

  • Review

MeSH terms

  • Cadherins / genetics
  • Cadherins / metabolism*
  • Epithelial Cells / metabolism
  • Epithelial Cells / pathology
  • Epithelial-Mesenchymal Transition / genetics
  • Epithelial-Mesenchymal Transition / physiology*
  • Epithelium / metabolism*
  • Epithelium / pathology
  • Fibrosis
  • Humans
  • Neoplasms / genetics
  • Neoplasms / metabolism
  • Neoplasms / pathology
  • Wnt Signaling Pathway / physiology*
  • beta Catenin / genetics
  • beta Catenin / metabolism*

Substances

  • Cadherins
  • beta Catenin