Correlation of cystatin-C with glomerular filtration rate by inulin clearance in pregnancy

Hypertens Pregnancy. 2012;31(1):22-30. doi: 10.3109/10641955.2010.507845. Epub 2011 Oct 18.

Abstract

Objective: To test utility of cystatin-C as a marker of glomerular filtration rate during pregnancy, we performed serial correlations with inulin clearance during pregnancy and postpartum.

Methods: Twelve subjects received inulin infusions and serum cystatin-C at three time points. Pearson's correlation coefficient was calculated.

Results: Cystatin-C levels ranged 0.66-1.48 mg/L during pregnancy, and 0.72-1.26 mg/L postpartum. Inulin clearance ranged 130-188 mL/min during pregnancy, and 110-167 mL/min postpartum. Cystatin-C did not correlate with inulin clearance at any time point.

Conclusion: Serum cystatin-C did not correlate with inulin clearance during pregnancy or postpartum.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Biomarkers / blood
  • Cystatin C / blood*
  • Female
  • Glomerular Filtration Rate*
  • Humans
  • Inulin*
  • Postpartum Period / physiology
  • Pregnancy / physiology*
  • Pregnancy Trimester, Second / physiology
  • Pregnancy Trimester, Third / physiology

Substances

  • Biomarkers
  • CST3 protein, human
  • Cystatin C
  • Inulin