Atacamycins A-C, 22-membered antitumor macrolactones produced by Streptomyces sp. C38

J Antibiot (Tokyo). 2011 Dec;64(12):775-80. doi: 10.1038/ja.2011.96. Epub 2011 Oct 19.

Abstract

Three new 22-membered macrolactone antibiotics, atacamycins A-C, were produced by Streptomyces sp. C38, a strain isolated from a hyper-arid soil collected from the Atacama Desert in the north of Chile. The metabolites were discovered in our HPLC-diode array screening and isolated from the mycelium by extraction and chromatographic purification steps. The structures were determined by mass spectrometry and NMR experiments. Atacamycins A, B and C exhibited moderate inhibitory activities against the enzyme phosphodiesterase (PDE-4B2), whereas atacamycin A showed a moderate antiproliferative activity against adeno carcinoma and breast carcinoma cells.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Antineoplastic Agents / chemistry
  • Antineoplastic Agents / isolation & purification
  • Antineoplastic Agents / pharmacology
  • Cell Line, Tumor
  • Chile
  • Cyclic Nucleotide Phosphodiesterases, Type 4 / metabolism
  • Desert Climate
  • Drug Screening Assays, Antitumor
  • Enzyme Inhibitors / chemistry
  • Enzyme Inhibitors / isolation & purification
  • Enzyme Inhibitors / pharmacology
  • Humans
  • Microbial Sensitivity Tests
  • Molecular Structure
  • Mycelium / chemistry
  • Nuclear Magnetic Resonance, Biomolecular
  • Polyketides / chemistry
  • Polyketides / isolation & purification*
  • Polyketides / metabolism*
  • Polyketides / pharmacology
  • Soil Microbiology
  • Spectrometry, Mass, Electrospray Ionization
  • Spectroscopy, Fourier Transform Infrared
  • Streptomyces / chemistry
  • Streptomyces / metabolism*

Substances

  • Antineoplastic Agents
  • Enzyme Inhibitors
  • Polyketides
  • Cyclic Nucleotide Phosphodiesterases, Type 4
  • PDE4B protein, human