Frequency of adverse reactions to influenza vaccine in the elderly. A randomized, placebo-controlled trial

JAMA. 1990 Sep 5;264(9):1139-41.


Concern about side effects constitutes a major deterrent to patient compliance with influenza vaccination, yet there is a paucity of data about the occurrence of adverse reactions in the population targeted for immunization. We conducted a randomized, double-blind, crossover trial to compare the frequency of adverse reactions following administration of 1988-1989 trivalent split-antigen influenza vaccine and saline placebo. Outpatient veterans 65 years of age or over (n = 336) were recruited by mail and were randomly assigned to receive vaccine followed 2 weeks later by placebo injection or placebo followed 2 weeks later by vaccine. There was no significant difference between influenza vaccine and placebo with respect ot the proportion of subjects reporting disability or systemic symptoms.

Publication types

  • Clinical Trial
  • Randomized Controlled Trial
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Aged
  • Double-Blind Method
  • Humans
  • Influenza Vaccines / adverse effects*
  • Influenza, Human / prevention & control*
  • Minnesota
  • Pilot Projects
  • Random Allocation
  • Randomized Controlled Trials as Topic


  • Influenza Vaccines