African American participation in Alzheimer's disease research that includes brain donation

Am J Alzheimers Dis Other Demen. 2011 Sep;26(6):469-76. doi: 10.1177/1533317511423020. Epub 2011 Oct 18.


Historically, minority groups have been underrepresented in research and clinical trials. The lack of participation by minorities has been attributed to a variety of factors including a mistrust of the predominately white research establishments and a lack of education about the purpose of research. The current study was designed to determine African American interest in Alzheimer's disease (AD) research and to recruit African Americans as normal controls in current AD studies with the goal of eventually gaining consent for brain donation upon death. Participants were 46 African Americans aged 65 or older, who were interviewed about the knowledge of medical procedures and experience with research. After initial recruitment interviews, 31.7% of participants agreed to yearly testing with eventual brain donation. Study findings suggest a moderate relationship between participants' knowledge of medical procedures used to prolong life and willingness to donate one's brain.

Publication types

  • Research Support, N.I.H., Extramural

MeSH terms

  • African Americans / psychology*
  • African Americans / statistics & numerical data
  • Aged
  • Alzheimer Disease / ethnology*
  • Alzheimer Disease / psychology*
  • Autopsy
  • Brain*
  • Female
  • Health Knowledge, Attitudes, Practice
  • Humans
  • Male
  • Patient Participation / psychology*
  • Patient Participation / statistics & numerical data
  • Patient Selection
  • Tissue Banks / statistics & numerical data
  • Tissue Donors / psychology*
  • Tissue Donors / statistics & numerical data