Heat shock proteins: immunity and immunopathology

Immunol Today. 1990 Jul;11(7):228-9. doi: 10.1016/0167-5699(90)90091-m.


Much interest has been generated in heat shock proteins (hsps) since they were implicated as dominant antigens of infectious microorganisms and suggested to have a role in the development of adjuvant arthritis (AA) in rats. Advances in the understanding of the role of hsps in immunity and immunopathology were recently discussed at a meeting held in Utrecht, as part of the European Community concerted action on immunopathogenesis and immunotherapy of chronic arthritis.

Publication types

  • Review

MeSH terms

  • Animals
  • Antigens / immunology*
  • Antigens, Bacterial / immunology
  • Arthritis, Experimental / immunology
  • Autoimmune Diseases / immunology
  • Bacterial Proteins / immunology
  • Cross Reactions
  • Diabetes Mellitus, Experimental / immunology
  • Heat-Shock Proteins / immunology*
  • Humans
  • Mice
  • Mice, Mutant Strains / immunology
  • Rats
  • Rats, Inbred Strains / immunology
  • Synovial Membrane / immunology


  • Antigens
  • Antigens, Bacterial
  • Bacterial Proteins
  • Heat-Shock Proteins