canSAR: An Integrated Cancer Public Translational Research and Drug Discovery Resource

Nucleic Acids Res. 2012 Jan;40(Database issue):D947-56. doi: 10.1093/nar/gkr881. Epub 2011 Oct 19.

Abstract

canSAR is a fully integrated cancer research and drug discovery resource developed to utilize the growing publicly available biological annotation, chemical screening, RNA interference screening, expression, amplification and 3D structural data. Scientists can, in a single place, rapidly identify biological annotation of a target, its structural characterization, expression levels and protein interaction data, as well as suitable cell lines for experiments, potential tool compounds and similarity to known drug targets. canSAR has, from the outset, been completely use-case driven which has dramatically influenced the design of the back-end and the functionality provided through the interfaces. The Web interface at http://cansar.icr.ac.uk provides flexible, multipoint entry into canSAR. This allows easy access to the multidisciplinary data within, including target and compound synopses, bioactivity views and expert tools for chemogenomic, expression and protein interaction network data.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Antineoplastic Agents / chemistry*
  • Antineoplastic Agents / pharmacology
  • Cell Line, Tumor
  • Databases, Genetic*
  • Drug Discovery
  • Gene Expression
  • Genetic Variation
  • Humans
  • Internet
  • Models, Molecular
  • Neoplasms / genetics*
  • Neoplasms / metabolism*
  • Protein Interaction Maps
  • RNA Interference
  • Systems Integration
  • Translational Medical Research

Substances

  • Antineoplastic Agents