Regenerative response following stab injury in the adult zebrafish telencephalon

Dev Dyn. 2011 Sep;240(9):2221-31. doi: 10.1002/dvdy.22710.


In contrast to mammals, the brain of the adult zebrafish has a remarkable ability to regenerate. In mammals, injuries induce proliferation of astrocytes and oligodendrocyte progenitors contributing to the formation of a glial scar. We analyzed the proliferation of glial cells and microglia in response to stab injury in the adult zebrafish telencephalon: Radial glial markers were up-regulated at the ventricle and co-expressed the proliferation nuclear antigen (PCNA). Microglia and oligodendrocyte progenitors accumulated transiently at the site of lesion. However, we could not find evidence of permanent scar formation. Parenchymal proliferation was almost negligible in comparison to the increase in proliferation at the ventricular zone. This suggests that most of the cellular material for regeneration is derived from regions of constitutive neurogenesis. Remarkably, the proliferative response is almost completely restricted to the lesioned hemisphere indicating that signals inducing regeneration remain mainly confined within the lesioned half of the telencephalon.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Immunohistochemistry
  • In Situ Hybridization
  • Neuroglia / cytology
  • Oligodendroglia / cytology
  • Proliferating Cell Nuclear Antigen / metabolism
  • Regeneration / physiology*
  • Telencephalon / cytology*
  • Telencephalon / physiology*
  • Zebrafish


  • Proliferating Cell Nuclear Antigen