Nucleated polymerisation in the presence of pre-formed seed filaments

Int J Mol Sci. 2011;12(9):5844-52. doi: 10.3390/ijms12095844. Epub 2011 Sep 9.

Abstract

We revisit the classical problem of nucleated polymerisation and derive a range of exact results describing polymerisation in systems intermediate between the well-known limiting cases of a reaction starting from purely soluble material and for a reaction where no new growth nuclei are formed.

Keywords: aggregation; amyloid; protein.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Algorithms*
  • Kinetics
  • Models, Chemical*
  • Polymerization*
  • Polymers / chemistry*

Substances

  • Polymers