Systematic approaches to toxicology in the zebrafish

Annu Rev Pharmacol Toxicol. 2012;52:433-53. doi: 10.1146/annurev-pharmtox-010611-134751. Epub 2011 Oct 19.

Abstract

As the current paradigms of drug discovery evolve, it has become clear that a more comprehensive understanding of the interactions between small molecules and organismal biology will be vital. The zebrafish is emerging as a complement to existing in vitro technologies and established preclinical in vivo models that can be scaled for high-throughput. In this review, we highlight the current status of zebrafish toxicology studies, identify potential future niches for the model in the drug development pipeline, and define the hurdles that must be overcome as zebrafish technologies are refined for systematic toxicology.

Publication types

  • Research Support, N.I.H., Extramural
  • Review

MeSH terms

  • Animals
  • Carcinogenicity Tests
  • Drug Delivery Systems
  • Drug Design
  • Drug Discovery
  • Drug Evaluation, Preclinical / methods*
  • Gastrointestinal Tract / drug effects
  • Heart / drug effects
  • Liver / drug effects
  • Models, Animal
  • Muscles / drug effects
  • Neurons / drug effects
  • Pharmaceutical Preparations
  • Pharmacokinetics
  • Phenotype
  • Toxicity Tests*
  • Zebrafish

Substances

  • Pharmaceutical Preparations