BRCA1 forks over new roles in DNA-damage response- before and beyond the breaks

Lei Li

doi:10.1016/j.molcel.2011.10.003

BRCA1 forks over new roles in DNA-damage response- before and beyond the breaks

Mol Cell. 2011 Oct 21;44(2):174-6. doi: 10.1016/j.molcel.2011.10.003.

Author

Lei Li¹

Affiliation

¹ Departments of Experimental Radiation Oncology and Genetics, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA. leili@mdanderson.org

Abstract

In this issue, Pathania et al. (2011) report the involvement of BRCA1 in ultraviolet (UV)-damage response at stalled replication forks, which extends the function of BRCA1 beyond its established role in the repair of DNA- double-strand breaks (DSBs), raising the complexity of how this tumor suppressor maintains genomic stability.

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