Oral administration of insulin-like growth factor-I from colostral whey reduces blood glucose in streptozotocin-induced diabetic mice

Br J Nutr. 2012 Jul 14;108(1):39-45. doi: 10.1017/S0007114511005198. Epub 2011 Oct 10.

Abstract

The aim of the present study was to investigate the effects of oral administration of the insulin-like growth factor-I-rich fraction (IGF-I-RF) from bovine colostral whey on the regulation of blood glucose levels in streptozotocin (STZ)-induced diabetic mice. We obtained a peptide fraction containing IGF-I (10 ng/mg protein) from Holstein colostrum within 24 h after parturition by using ultrafiltration. The blood glucose levels of STZ-induced diabetic mice fed with IGF-I-RF (50 μg/kg per d) were significantly reduced by 11 and 33 % at weeks 2 and 4, respectively (P < 0·05). The body weights of STZ-induced diabetic mice increased following the oral administration of the IGF-I-RF. The kidney weights of STZ-induced diabetic mice decreased significantly (P < 0·05) following the administration of the IGF-I-RF, and the liver weights of STZ-induced diabetic mice decreased significantly (P < 0·05) following the administration of 50 μg/kg per d of the IGF-I-RF. The present results indicate that the IGF-I-RF obtained from Holstein colostrum could be a useful component for an alternative therapeutic modality for the treatment of diabetes in insulin-resistant patients.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Blood Glucose / drug effects*
  • Body Weight / drug effects
  • Cattle
  • Colostrum / chemistry*
  • Diabetes Mellitus, Experimental / drug therapy*
  • Glucose Tolerance Test
  • Insulin-Like Growth Factor I / chemistry
  • Insulin-Like Growth Factor I / pharmacology*
  • Kidney / drug effects
  • Kidney / pathology
  • Liver / drug effects
  • Liver / pathology
  • Male
  • Mice
  • Milk Proteins / chemistry*
  • Organ Size
  • Random Allocation
  • Spleen / drug effects
  • Spleen / pathology
  • Triglycerides / metabolism
  • Whey Proteins

Substances

  • Blood Glucose
  • Milk Proteins
  • Triglycerides
  • Whey Proteins
  • Insulin-Like Growth Factor I