An inversion truncating the creA gene of Aspergillus nidulans results in carbon catabolite derepression

Mol Microbiol. 1990 May;4(5):851-4. doi: 10.1111/j.1365-2958.1990.tb00656.x.

Abstract

The creAd-30 mutation leading to carbon catabolite derepression in Aspergillus nidulans is a pericentric inversion, having one breakpoint within the creA gene on the left arm of chromosome I and the other breakpoint between binG and yA on the right arm. The left-arm breakpoint alters the creA transcript. The likelihood that the inversion truncates creA centrally strengthens a previous proposal that derepression is the phenotype of loss-of-function mutations in creA.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Aspergillus nidulans / drug effects
  • Aspergillus nidulans / genetics*
  • Chromosome Inversion*
  • Chromosomes, Fungal / ultrastructure
  • Genes, Fungal*
  • RNA, Messenger / biosynthesis
  • RNA, Messenger / genetics*
  • Restriction Mapping
  • Transcription, Genetic

Substances

  • RNA, Messenger