Association between equivalent current dipole source localization and focal cortical dysplasia in epilepsy patients

Epilepsy Res. 2012 Feb;98(2-3):223-31. doi: 10.1016/j.eplepsyres.2011.09.018. Epub 2011 Oct 21.


We analysed the association between focal cortical dysplasia (FCD) visible in MRI and the location of equivalent current dipole (ECD) of single interictal scalp EEG spikes (IIS) in 11 epilepsy patients. We calculated several indicators of distance of ECDs to the FCD border. The results confirm some previous studies suggesting that the epileptogenic zone associated to the location of ECDs extends beyond the FCD visible in MRI. The analysis suggests the ECDs to be in a shell parallel to part of the FCD surface.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adolescent
  • Adult
  • Brain Mapping*
  • Brain Waves / physiology*
  • Cerebral Cortex / physiopathology*
  • Electrodes
  • Electroencephalography
  • Epilepsy / complications
  • Epilepsy / pathology*
  • Female
  • Humans
  • Image Processing, Computer-Assisted
  • Magnetic Resonance Imaging
  • Male
  • Malformations of Cortical Development / complications
  • Malformations of Cortical Development / pathology*
  • Young Adult